Lead Investigator: Leo Buckley, Brigham and Women’s Hospital
Title of Proposal Research: Colchicine Adverse Effects Research in people with Covid-19 randomized to colchicine treatment
Vivli Data Request: 8700
Funding Source: NHLBI K23HL150311
Potential Conflicts of Interest: None
Summary of the Proposed Research:
Colchicine is an established anti-inflammatory therapy used to treat hereditary auto-inflammatory conditions and pericarditis. Colchicine also can reduce the risk of certain types of heart disease. Unfortunately, colchicine can cause nausea, vomiting, diarrhea and stomach cramping. These side effects, and others, limit the use of colchicine. Certain characteristics and drug-drug interactions may identify people with high risk of colchicine side effects. Identifying those “risk factors” may help clinicians minimize colchicine’s side effects.
The overall goal of this project is to better understand how colchicine’s side effects impact its beneficial anti-inflammatory effects. Colchicine is known to cause stomach-related issues, such as nausea and vomiting, but the factors that predict and modify these side effects are unknown. The results of this project may help clinicians who prescribe colchicine for cardiovascular and other conditions.
Requested Studies:
Colchicine Coronavirus SARS-CoV2 Trial (COLCORONA)
Data Contributor: Montreal Heart Institute
Study ID: NCT04322682
Sponsor ID: MHIPS-2020-001