Covid-19 Pulmonary Gene Expression Analysis

Lead Investigator: Matt Linnik, Eli Lilly & Co.
Title of Proposal Research: Covid-19 Pulmonary Gene Expression Analysis
Vivli Data Request: 5960
Funding Source: None
Potential Conflicts of Interest: None

Summary of the Proposed Research:

It is not known how specific immune cell types influence pathology in convalescent covid-19 patients. This study aims to identify differences that may exist to further this understanding.

Statistical Analysis Plan:

1) Take raw gene expression data and aggregate as biologically relevant “pathway modules” and “cell type modules”

2)  Look for enriched eigengene scores for “pathway modules” and “cell type modules” between covid-19 vs influenza and covid-19 vs healthy

3)  Compare gene expression to histology findings

Requested Studies:

COVID-19: Pulmonary Vascular Endothelialitis, Thrombosis and Angiogenesis
Sponsor: Hannover Medical School

Public Disclosure:

Data Request title: Covid-19 Pulmonary Gene Expression Analysis