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Center for Global Research Data

Distribution of interleukin-6 in human plasma implications for statistical modelling and meta-analysis

Lead Investigator: Gustav Nilsonne, Karolinska Institutet
Title of Research Proposal: Distribution of interleukin-6 in human plasma implications for statistical modelling and meta-analysis
Vivli Data Request: 3361
Funding Source: None
Potential Conflicts of Interest: None
Summary of the Proposed Research: 
Many biological variables are approximately exponentially distributed. A priori knowledge of the expected distribution of a variable enables researchers to plan analyses and make decisions about variable transformation and statistical modelling. Interleukin-6 (IL-6) is a cytokine released by cells of the immune system when an inflammatory response is activated, and it signals to multiple organs, including the other cells of the immune system, the liver, and the brain. Data on circulating IL-6 from humans are often log-transformed in order to approximate a normal distribution, but no systematic analysis of the distribution of IL-6 levels has been presented to our knowledge. The current investigation will investigate whether data on cytokines such as IL-6 should be log-transformed to follow a normal distribution and hence allow for statistical analyses which assume a normal distribution. The current project is relevant to current research in immunology, where no standard exists regarding data transformation. The development of such a standard would contribute to the improvement of research into IL-6 as a biomarker.
Requested Studies:
Assessment of the Anti-Inflammatory Activity, Efficacy and Safety of Intravenous SB-681323 in Subjects at Risk for Development of Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS).
Sponsor: GlaxoSmithKline
Study ID: NCT00996840
Sponsor ID: 111592
A Six Week Randomized, Double-blind, Multi-center, Placebo-controlled, Exploratory, Adaptive Design Study to Explore the Antidepressant Properties of the p38 MAP Kinase Inhibitor GW856553 Compared to Placebo in Adult Subjects With Major Depressive Disorder
Sponsor: GlaxoSmithKline
Study ID: NCT00976560
Sponsor ID: 113009
A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety of 12 Weeks of Dosing With GW856553 and Its Effects on Inflammatory Markers, Infarct Size, and Cardiac Function in Subjects With Myocardial Infarction Without ST-segment Elevation
Sponsor: GlaxoSmithKline
Study ID: NCT00910962
Sponsor ID: 111810
Durable-Response Therapy Evaluation For Early or New-Onset Type 1 Diabetes – DEFEND
Sponsor: GlaxoSmithKline
Study ID: NCT00678886
Sponsor ID: 115495
The PRIMO Study: Paricalcitol Capsules Benefits in Renal Failure Induced Cardiac Morbidity in Subjects With Chronic Kidney Disease Stage 3/4
Sponsor: AbbVie
Study ID: NCT00497146
Sponsor ID: M10-030
An International, Multicenter, Randomized, Placebo-controlled, Parallel-group, 1 Year Treatment, Integrated Biomarkers and Imaging Study in Subjects With Angiographically Documented Coronary Heart Disease (CHD) to Examine the Effects of the Novel Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Inhibitor SB-480848 on Intermediate Cardiovascular Endpoints, Patient Safety and Tolerability
Sponsor: GlaxoSmithKline
Study ID: NCT00268996
Sponsor ID: SB-480848/026