Center for Global Research Data

External validation of the AIQ predictive score of clinical benefit using Sodium Fluoride (NaF) position emission tomography/computed tomography (PET/CT) images in metastatic prostate cancer (mPC)

Lead Investigator: Timothy Perk, AIQ Solutions
Title of Proposal Research: External validation of the AIQ predictive score of clinical benefit using Sodium Fluoride (NaF) position emission tomography/computed tomography (PET/CT) images in metastatic prostate cancer (mPC).
Vivli Data Request: 7144
Funding Source: None
Potential Conflicts of Interest: None

Summary of the Proposed Research:

Between 2003 and 2017, the percentage of patients diagnosed with metastatic prostate cancer increased from 4% to 8%. This increase occurred even though the overall age-adjusted incidence of prostate cancer in the United States went down from 155 per 100,000 in 2003, to 105 per 100,000 in 2017.

AIQ has developed a predictive score that can predict progression free survival of metastatic prostate cancer (mPC) patients using Sodium Fluoride (NaF) position emission tomography/computed tomography (PET/CT) imaging. We hope to use this data as one of three external validation sets to prove that the score is generalizable. If the score is shown to be both predictive and generalizable, we hope to include it in future clinical studies as a way to provide early go no-go decisions.

Requested Studies:

A PHASE 2, OPEN-LABEL, SINGLE-ARM STUDY OF 18F-SODIUM FLUORIDE PET/CT BONE IMAGING IN ENZALUTAMIDE-TREATED CHEMOTHERAPY-NAÏVE PATIENTS WITH BONE-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
Data Contributor: Pfizer Inc.
Study ID: NCT02384382
Sponsor ID: NCT02384382