Lead Investigator: Dawn Farrell, Institute of Technology Tralee
Title of Proposal Research: Interventions for fatigue in inflammatory bowel disease
Vivli Data Request: 3246
Funding Source: Government Funding: A Cochrane Fellowship was provided by the Health Research Board of Ireland
Potential Conflicts of Interest: None
Summary of the Proposed Research:
Review question: What are the effects of treatments on fatigue in individuals with inflammatory bowel disease (IBD) compared to no treatment or placebo?
Background: Inflammatory bowel disease is a life-long illness that causes inflammation and ulceration in the gut. Crohn’s disease and ulcerative colitis are the two main types of IBD. People living with IBD often experience fatigue, which can be quite burdensome and negatively impact on their quality of life. Different treatments, such as medications and exercise, may improve fatigue. However, it is unclear what the effects of such treatments on fatigue in IBD are. This review presents the available evidence of the effectiveness of treatments on fatigue in IBD and will help healthcare professionals and patient manage the problematic symptom of fatigue.
Method: A systematic search of the databases MEDLINE, CINAHL, EMBASE and PsycINFO was undertaken from inception to April 2017. We also searched the Cochrane IBD Group Specialized Register, the Cochrane Central Register of Controlled trials (CENTRAL), ongoing trials and research registers (Current Controlled Trials; ClinicalTrials and the WHO International Clinical Trials Registry Platform), conference abstract and reference lists for potentially eligible studies.
Selection criteria: Randomised controlled trials of pharmacological and non-pharmacological interventions in children or adults with IBD, where fatigue was assessed as a primary or secondary outcome using a generic or disease specific fatigue measure, a subscale of a larger quality of life scale or as a single item measure were included.
Data collection and analysis: Standard methodological procedures expected by Cochrane were used.
Publication plan: The review will be published in the Cochrane library
Requested Studies:
An Open-Label, Multicenter, Efficacy and Safety Study to Evaluate Two Treatment Algorithms in Subjects With Moderate to Severe Crohn’s Disease (CALM)
Sponsor: AbbVie
Study ID: NCT01235689
Sponsor ID: M11-271
Update: This data request was withdrawn on 15 November 2020 by the researcher.