Meta-analysis of early stroke recurrence rate in minor stroke

Lead Investigator: Andy Lim, Monash University
Title of Proposal Research:
Meta-analysis of early stroke recurrence rate in minor stroke
Vivli Data Request:
Funding Source:
Potential Conflicts of Interest:

Summary of the Proposed Research:

Having a ‘mini-stroke’ (TIA = transient ischaemic attack) or ‘minor stroke’ is dangerous to health, as it can signal a recurrent and much larger stroke that can cause disability or death. Most of the previous research efforts have been to measure and reduce this recurrence rate in the TIA group, but ‘minor stroke’ has not had the same attention. Large international trials have been released that shows that this minor stroke group can be helped in a similar way. The next step then is to measure how high the recurrence rate is in this new cohort of patients. That is why we are performing a study called a ‘meta-analysis’, that summarizes all the known recurrence rates that have been published into one single figure. This will help hospitals and health services benchmark their minor stroke interventions.

Previous meta-analytic efforts have focused on stroke recurrence in TIA. However recent clinical trials have demonstrated favourable outcome of early secondary prevention in an extended subgroup that includes minor stroke. Reliable risk estimation of this contemporary cohort is required for service planning given these advances. This study therefore aims to report the early stroke recurrence rate for such a cohort.

Requested Studies:

Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack (SOCRATES trial)
Sponsor: AstraZeneca
Study ID: NCT01994720
Sponsor ID: NCT01994720