Center for Global Research Data

Pandemic response COVID-19 Research Collaboration Platform

Lead Investigator: Dan Hanley, Johns Hopkins University
Title of Proposal Research: Pandemic response COVID-19 Research Collaboration Platform
Vivli Data Request: 6765
Funding Source: Funding is via an administrative supplement mechanism of an existing NCATS award
Potential Conflicts of Interest: None

Summary of the Proposed Research:

Project background: Over 500,000 Americans have died of COVID-19 and many more COVID-19 deaths are expected. Lessons must be learned from successes and failures in response to the pandemic. Therefore, we are conducting a pooled analysis of prior studies and its efficacy for hydroxychloroquine (and chloroquine) in hospitalized patients with COVID-19 – to provide closure for these drugs in this pandemic – we summarize relevant key studies.

Furthermore, vaccines which are being deployed, and therapeutics which have been difficult to operationalize with evidence basis, are needed. Herein, after publication of cognizance of the negative saga might help prevent repetition with other therapeutics and vaccines in the future pandemic response.

Vivli will be a repository for the 7 studies that will be analyzed in response to the pooling effort of the COVID-19 research collaboration platform

Requested Studies:

Treating COVID-19 With Hydroxychloroquine: A Multicenter Randomized, Double-blind, Placebo-controlled Clinical Trial in Hospitalized Adults
Sponsor: NYU Langone Health
Study ID: NCT04369742
Sponsor ID: 20-00463

Hydroxychloroquine vs. Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-19 (HAHPS): A Prospective Pragmatic Trial
Sponsor: Intermountain Health Care, Inc.
Study ID: NCT04329832
Sponsor ID: 1051355

WU 352: Open-label, Randomized Controlled Trial of Hydroxychloroquine Alone or Hydroxychloroquine Plus Azithromycin or Chloroquine Alone or Chloroquine Plus Azithromycin in the Treatment of SARS CoV-2 Infection
Sponsor: Washington University School of Medicine
Study ID: NCT04341727
Sponsor ID: 202003188

COVIDMED-Comparison Of Therapeutics for Hospitalized Patients Infected With SARS-CoV
Sponsor: Bassett Research Institute
Study ID: NCT04328012
Sponsor ID: NCT04328012

A Randomized, Controlled Clinical Trial of the Safety and Efficacy of Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Patients
Sponsor: Queen’s Medical Centre
Study ID: NCT04345692
Sponsor ID: RA-2020-018

Pragmatic Factorial Trial of Hydroxychloroquine, Azithromycin, or Both for Treatment of Severe SARS-CoV-2 Infection
Sponsor: Duke University
Study ID: NCT04335552
Sponsor ID: PRO00105339

Treatment in Patients With Suspected or Confirmed COVID-19 With Early Moderate or Severe Disease: A Randomized Clinical Trial
Sponsor: LCMC Health
Study ID: NCT04344444
Sponsor ID: COVID 2020-001