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Center for Global Research Data

Phenotypic Characterization of Chronic Neuropathic Pain Following Post-Traumatic and Post-Surgical Injury

Lead Investigator: John Markman, University of Rochester
Title of Proposal Research: Phenotypic Characterization of Chronic Neuropathic Pain Following Post-Traumatic and Post-Surgical Injury
Vivli Data Request: 4326
Funding Source: No
Potential Conflicts of Interest: None

Summary of the Proposed Research:

More than 300 million surgeries are performed worldwide each year. Chronic pain after surgery typically lasts for more than 3 months after the operation, has a different feeling, and is often more intense than pain before surgery. This type of pain occurs in everyone or two of 10 surgical patients and is intolerable after roughly one of every 100 operations. This serious pain is more common after some types of surgery like those where the operation occurs in the chest to treat lung or breast cancer and influences how often this problem occurs and the severity of the pain. Nerve injury- related pain is a factor in one third of these patients. There is great unmet need for nonopioid analgesics for the treatment of nerve injury-related pain. A major barrier to optimizing treatment matching is a limited understanding of the relationship between sensory features identified on exam and by history and underlying pain mechanism. Additional study of this robustly phenotyped cohort with post-surgical and post traumatic neuropathic pain will address this barrier to improved pain diagnosis and treatment matching as well as superior clinical trial designs.

Requested Studies:

A Randomized Double Blind Placebo Controlled Parallel Group Study Of The Efficacy And Safety Of Pregabalin (Bid) In Subjects With Post-traumatic Peripheral Neuropathic Pain
Sponsor: Pfizer, Inc.
Study ID: NCT01701362