The RAAS inhibition in COVID-19 Trialists Collaboration (RiCTC)

Lead Investigator: Meg Jardine, The University of Sydney
Title of Proposal Research: The RAAS inhibition in COVID-19 Trialists Collaboration (RiCTC)
Vivli Data Request: 8656
Funding Source: The study has been funded through an investigator-initiated grant from the National Health and Medical Research Council’s (NHMRC) Medical Research Future Fund (MRFF) – 2020 Respiratory Medicine Clinical Trials Research on COVID-19 Grant Opportunity (MRF2002277).
Potential Conflicts of Interest: None

Summary of the Proposed Research:

The Renin Angiotensin Aldosterone System (RAAS) has been widely researched within the COVID-19 setting since the start of the global pandemic in 2019. Several studies exist which evaluate the safety and efficacy of RAAS inhibition for the treatment of COVID-19 in varying populations, however, due to the pandemic, these studies have experienced significant barriers to completion. These limitations mean many studies may not have produced results with enough power to analyse clinically relevant outcomes in a single trial alone.

This collaboration combines the individual participant-level data (IPD) from several global trials randomising participants to RAAS inhibition versus placebo or standard of care during the pandemic to conduct a meta-analysis to estimate outcomes relating to the safety and efficacy of the use of renin angiotensin blockade for COVID-19. This meta-analysis will also allow for further subgroup analyses to be conducted to maximise global learnings on the use of these agents.

Requested Studies:

Randomized Controlled Trial of Losartan for Patients With COVID-19 Not Requiring Hospitalization
Data Contributor: University of Minnesota
Study ID: NCT04311177
Sponsor ID: SURG-2020-28683

Randomized Controlled Trial of Losartan for Patients With COVID-19 Requiring Hospitalization
Data Contributor: University of Minnesota
Study ID: NCT04312009
Sponsor ID: SURG-2020-28675

COVIDMED-Comparison Of Therapeutics for Hospitalized Patients Infected With SARS-CoV
Data Contributor: Bassett Medical Center
Study ID: NCT04328012
Sponsor ID: NCT04328012