Lead Investigator: Junhao Hu, Chinese Academy of Science
Title of Proposal Research: Vessel pericytes NO-sGC signaling in COVID-19
Vivli Data Request: 5901
Funding Source: None
Potential Conflicts of Interest: None
Summary of the Proposed Research:
Previously we found NO-sGC signaling was dramatically decreased on LPS induced Acute Respiratory Distress Syndrome (ARDS) model. Further using clinal drug Riociguat, a sGC activator, can efficient improve the lung leakage symptom. And we also found sGC was highly specifically expressed in vessel pericytes, which was a overlooked cell type in various diseases (lung/liver fibrosis).
Considering the ARDS induced by recent emerging COVID-19, we were wondering if sGC signaling decreased in this process. And if it was, can targeting lung pericytes sGC signaling improve COVID-19 survival rate.
COVID-19: Pulmonary Vascular Endothelialitis, Thrombosis and Angiogenesis
Sponsor: Hannover Medical School